Publications
Létoffé, S., Wu, Y., Darch, S.E., Beloin, C., Whiteley, M., Touqui, L., Ghigo, J.M. (2022) Volatile hydrogen cyanide released by Pseudomonas aeruginosa provides a competitive advantage over Staphylococcus aureus in biofilm and in vivo lung environment. mBio 2022 Oct 26;13(5):e0215422 doi: 10.1128/mbio.02154-22. Epub 2022 Sep 21.
Sacco, M.D., Defrees, K., Zhang, X., Lawless, W., Nwanochie, E., Balsizer, A., Darch, S.E., Renslo, A.R., Chen, Y. (2022). Structure-based ligand design targeting Pseudomonas aeruginosa LpxA in lipid A biosynthesis. ACS Infectious Diseases DOI: 10.1021/acsinfecdis.1c00650 PMID: 35653508
Gannon, A. & Darch, S.E. (2021) Real time assessment of antimicrobial tolerance in bacterial aggregates. J. Vis. Exp. (170), e62420, doi:10.3791/62420.
Gannon, A. & Darch, S.E. (2021) Same game, different players: emerging pathogens of the CF lung. mBio. 12:e01217-20.
Kroeck, K.G., Sacco, M.D., Smith, E.W., Zhang, X., Shoun, D., Akhtar, A., Darch, S.E., Cohen, F., Andrews, L.D., Knox, J.E. and Chen, Y., (2019). Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Scientific reports, 9(1), pp.1-12
Darch, S.E. & Koley, D (2018) Quantifying microbial chatter: Scanning electrochemical microscopy (SECM) as a tool to study interactions in biofilms. Royal Society Proceedings A.
Darch, S.E., Fitzpatrick, M., Simoska, O., Barraza, J.P., Stevenson, K.J., Bonnecaze, R.T., Shear, J.B. and M. Whiteley (2018) Spatial determinants of quorum signaling in a Pseudomonas aeruginosa infection model. Proceedings of the National Academy of Sciences USA. 2018 May 1;115(18):4779-4784
Darch, S.E., Kragh, K.N., Abbott, E.A., Bjarnsholt, T., Bull, J.J. and Whiteley, M., (2017). Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model. mBio, 8(2), pp.e00240-17
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H.L., Paszkiewicz, K., Holden, S., Fogarty, A., Crusz, S.A. and Diggle, S.P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific reports 5
Darch, S. E., West, S. A., Winzer, K. & Diggle, S. P. (2012) Density-dependent fitness benefits in quorum sensing bacterial populations. Proceedings of the National Academy of Sciences USA. 109: 8259-8263.
Stacy, A., McNally, L., Darch, S.E., Brown, S.P. and Whiteley, M. (2016) The biogeography of polymicrobial infection. Nature Reviews Microbiology. 14:93-105.
Sønderholm, M., Kragh, K.N., Koren, K., Jakobsen, T.H., Darch, S.E., Alhede, M., Jensen, P.Ø., Whiteley, M., Kühl, M. and Bjarnsholt, T., (2017). Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics. Applied and Environmental Microbiology, 83(9), pp.e00113-17.
Darch, S. E., & Whiteley, M. (2015). Show Me the SNPs. How Bacterial Sex Generates Diversity in the Cystic Fibrosis Lung. American journal of respiratory and critical care medicine, 191(7), 725-727.
Darch, S.E., Ibberson, C.B. and Whiteley, M., (2017). Evolution of Bacterial “Frenemies”. mBio, 8(3), pp.e00675-17.
For a list of all publications:
https://scholar.google.com/citations?user=c-bMcNcAAAAJ&hl=en
https://www.ncbi.nlm.nih.gov/myncbi/sophie.darch.1/bibliography/public/
Sacco, M.D., Defrees, K., Zhang, X., Lawless, W., Nwanochie, E., Balsizer, A., Darch, S.E., Renslo, A.R., Chen, Y. (2022). Structure-based ligand design targeting Pseudomonas aeruginosa LpxA in lipid A biosynthesis. ACS Infectious Diseases DOI: 10.1021/acsinfecdis.1c00650 PMID: 35653508
Gannon, A. & Darch, S.E. (2021) Real time assessment of antimicrobial tolerance in bacterial aggregates. J. Vis. Exp. (170), e62420, doi:10.3791/62420.
Gannon, A. & Darch, S.E. (2021) Same game, different players: emerging pathogens of the CF lung. mBio. 12:e01217-20.
Kroeck, K.G., Sacco, M.D., Smith, E.W., Zhang, X., Shoun, D., Akhtar, A., Darch, S.E., Cohen, F., Andrews, L.D., Knox, J.E. and Chen, Y., (2019). Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Scientific reports, 9(1), pp.1-12
Darch, S.E. & Koley, D (2018) Quantifying microbial chatter: Scanning electrochemical microscopy (SECM) as a tool to study interactions in biofilms. Royal Society Proceedings A.
Darch, S.E., Fitzpatrick, M., Simoska, O., Barraza, J.P., Stevenson, K.J., Bonnecaze, R.T., Shear, J.B. and M. Whiteley (2018) Spatial determinants of quorum signaling in a Pseudomonas aeruginosa infection model. Proceedings of the National Academy of Sciences USA. 2018 May 1;115(18):4779-4784
Darch, S.E., Kragh, K.N., Abbott, E.A., Bjarnsholt, T., Bull, J.J. and Whiteley, M., (2017). Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model. mBio, 8(2), pp.e00240-17
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H.L., Paszkiewicz, K., Holden, S., Fogarty, A., Crusz, S.A. and Diggle, S.P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific reports 5
Darch, S. E., West, S. A., Winzer, K. & Diggle, S. P. (2012) Density-dependent fitness benefits in quorum sensing bacterial populations. Proceedings of the National Academy of Sciences USA. 109: 8259-8263.
Stacy, A., McNally, L., Darch, S.E., Brown, S.P. and Whiteley, M. (2016) The biogeography of polymicrobial infection. Nature Reviews Microbiology. 14:93-105.
Sønderholm, M., Kragh, K.N., Koren, K., Jakobsen, T.H., Darch, S.E., Alhede, M., Jensen, P.Ø., Whiteley, M., Kühl, M. and Bjarnsholt, T., (2017). Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics. Applied and Environmental Microbiology, 83(9), pp.e00113-17.
Darch, S. E., & Whiteley, M. (2015). Show Me the SNPs. How Bacterial Sex Generates Diversity in the Cystic Fibrosis Lung. American journal of respiratory and critical care medicine, 191(7), 725-727.
Darch, S.E., Ibberson, C.B. and Whiteley, M., (2017). Evolution of Bacterial “Frenemies”. mBio, 8(3), pp.e00675-17.
For a list of all publications:
https://scholar.google.com/citations?user=c-bMcNcAAAAJ&hl=en
https://www.ncbi.nlm.nih.gov/myncbi/sophie.darch.1/bibliography/public/